Pro Football Talk has a scouting report for our game written by former Broncos GM Ted Sundquist.  In a nutshell, his keys are:

1) Texans must establish confidence in their offense

2) DeMeco is most important in stopping Titans' running game

3) Titans must open up passing game (downfield) with pocket-comfortable Collins under center

4) Fat Albert

5) 'Dre Davis must help Texans by establishing good field position, and possibly breaking one

Go read it.  It is excellent stuff.